Strong Laboratory for Computational Genomics

Integrated Center for Genes, Environment, and Health
National Jewish Health, Denver, CO




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Publications

... Rebecca M. Davidson, Benjamin Garcia, Rafael Silva Duarte, Mary Jackson, Michael Strong. Submitted. (2013).

... Agatha Wieczorek, Jolynn Troudt, Phillip Knabenbauer, Jennifer Taylor, Rebecca Pavlicek, Russell Karls, Anne Hess, Rebecca Davidson, Michael Strong, Helle Bielefeldt-Ohmann, Angelo Izzo, Karen Dobos. Submitted. (2013).

Galectin-9 functionally impairs natural killer (NK) cells in humans and mice.
Lucy Golden-Mason, Rachel McMahan, Michael Strong, Richard Reisdorph, Spencer Mahaffey, Brent Palmer, Linling Cheng, Caroline Kulesza, Mitsuomi Hirashima, Toshiro Niki, and Hugo Rosen. Journal of Virology, Feb 13 [Epub ahead of print]. (2013).

Translating basic science insight into public health action for multidrug- and extensively drug-resistant tuberculosis.
Walter ND, Strong M, Belknap R, Ordway DJ, Daley CL, Chan ED. Respirology. 17(5):772-791. (2012).

Research, Collaboration, and Open Science using Web 2.0. Kevin Shee*, Michael Strong*, Nicholas J. Guido, Robert Lue, George M. Church, Alain Viel. *Equal contribution, Journal of Microbiology and Biology Education, 11:2 p130-134, (2010).

Reducing Global Health Disparities through Research, Education, and International Collaboration .
Michael Strong. Center for Strategic and International Studies, Smart Global Health Policy Report p47-48 (2010). Research Spotlight , Full Report

Tuberculosis Drug Resistance Mutation Database .
Andreas Sandgren, Michael Strong, Preetika Mutukrishnan, Brian K. Weiner, George M. Church, Megan B. Murray. PLoS Medicine 6:2 (2009). Link , Database

The Protein Network as a Tool for Finding Novel Drug Targets.
Michael Strong and David Eisenberg. Book Chapter in Systems Biological Approaches in Infectious Diseases. Edited by H.I.M Boshoff and C.E. Barry III, Birkhauser. Verlag Publishing. Progress in Drug Research, 64:191, 193-215 (2007). Link

Functional linkages can reveal protein complexes for structure determination.
Kim SM, Bowers PM, Pal D, Strong M, Terwilliger TC, Kaufmann M, Eisenberg D. Structure 15:1079-89 (2007). Link

Gem of an idea for a unique machine.
Michael Strong and George Church. Nature 447:112 (2007).

Toward the Structural Genomics of Complexes: Crystal Structure of a PE/PPE protein complex from Mycobacterium tuberculosis.
Michael Strong, Michael Sawaya, Shuishu Wang, Martin Philips, Duilio Cascio, and David Eisenberg. Proc. Natl. Acad. Sci. U. S. A. 103:8060-8065 (2006). Link PDB Proteopedia Link

Structural Proteomics and Computational Analysis of a Deadly Pathogen: Combating M. tuberculosis from Multiple Fronts.
Michael Strong and Celia Goulding. Book Chapter (Chapter 15) in Microbial Proteomics: Functional Biology of Whole Organisms. Edited by Ian Humphrey-Smith and Michael Hecker. Wiley Publishing, Inc. Methods Biochem Analysis 49:245-69 (2006). Link

Unique Transcriptome Signature of Mycobacterium tuberculosis in Pulmonary Tuberculosis.
Helmy Rachman, Michael Strong, Timo Ulrichs, Leander Grode, Johannes Schuchhardt, Hans Mollenkopf, George A. Kosmiadi, David Eisenberg, S.H.E. Kaufmann. Infection and Immunity 74:1233-1242. (2006). Link

Mycobacterium tuberculosis Gene Expression Profiling within the Context of Protein Networks.
Helmy Rachman*, Michael Strong*, Ulrich Schaible, Johannes Schuchhardt, Kristine Hagens, Hans Mollenkopf, David Eisenberg, Stefan H.E. Kaufmann. *Equal Contribution. Microbes and Infection. 8:747-757 (2006). Link

A specific secretion system mediates PPE41 transport in pathogenic mycobacteria.
Abdallah M. Abdallah, Theo Verboom, Fredericke Hannes, Mohamad Safi, Michael Strong, David Eisenberg, Rene Musters, Christina M.J.E. Vandenbroucke-Grauls, Ben J. Appelmelk, Joen Luirink4 and Wilbert Bitter. Molecular Microbiology 62:667-79 (2006). Link

Scientists and Societies: Community Outreach.
Michael Strong. Nature. 434, 418. (2005). Link

Protein Nanomachines.
Michael Strong. PLoS Biology Mar, 2:E73. (2004). Link

A Web-Based Comparative Genomics Tutorial for Investigating Microbial Genomes.
Michael Strong, Duilio Cascio, and David Eisenberg. ASM Microbiology Education Journal 5: 30-35. (2004). Link

Genomes, Maps, and Modules: Navigating the M. tuberculosis Genome.
Michael Strong. UCLA Scientific Review 1: 28-32. (2004). Link

Visualization and Interpretation of Protein Networks in Mycobacterium tuberculosis Based on Hierarchical Clustering of Genome-Wide Functional Linkage Maps.
Michael Strong, Thomas G. Graeber, Morgan Beeby, Matteo Pellegrini, Michael J. Thompson, Todd O. Yeates, and David Eisenberg. Nucleic Acids Research, 31: 7099-7109. (2003). Link

Inference of Protein Function and Protein Linkages in M. tuberculosis Based on Prokaryotic Genome Organization: A Combined Computational Approach.
Michael Strong, Parag Mallick, Matteo Pellegrini, Michael J. Thompson, and David Eisenberg. Genome Biology 4:R59.1-R59.16. (2003). Link

2'-Ribose-ferrocene oligonucleotides for electronic detection of nucleic acids.
Yu CJ, Wang H, Wan Y, Yowanto H, Kim JC, Donilon LH, Tao C, Strong M, Chong Y. Journal of Organic Chemistry 66:2937-2942. (2001). Link

Uridine-Conjugated Ferrocene DNA Oligonucleotides: Unexpected Cyclization Reaction of the Uridine Base.
Yu, C. J.; Yowanto, H.; Wan, Y.; Meade, T. J.; Chong, Y.; Strong, M.; Donilon, L. H.; Kayyem, J. F.; Gozin, M.; Blackburn, G. F. Journal of the American Chemical Society. 122: 6767-6768. (2000). Link


Published Online

Michael Strong. NextGen VOICES, top online essay category, Response: Describe a specific experience and how it changed your science, training, or career goals. Science Online, July (2012).

Michael Strong. NextGen VOICES, top online essay category, Response: You've just been elected to your nation's highest office! In your inaugural address, announce the biggest challenge facing your country today and how you will use science to address it. Science Online, January (2013).

Genomic and computational analysis of Mycobacterium tuberculosis drug resistance.
Gargi Datta, Rebecca Davidson, Jessica Taylor, Nabeeh Hasan, Benjamin Garcia, Michael Strong. Faculty of 1000, F1000 Posters 4: 164. (2013).